“Only American citizens should vote in our elections.” (first campaign ad, released 2026-07-30)

“I'm all for supporting and funding ICE. I support law enforcement. President Trump has done a great job protecting our borders.” (August 3 debate)

“If they build nuclear missiles, their goal is to come here and kill us. So the more we can fight them over there and prevent it over there, the better for the United States.” (August 3 debate)

Distinguishing her position from her late brother's, Graham backed ending the filibuster: “I'm all for getting rid of the filibuster, because eventually the Democrats are going to get rid of it anyway.” (August 3 debate)

Voiced “unabashed support” for data centers. (August 3 debate)

Opposes abortion: “Every life is precious.” (first campaign ad, released 2026-07-30)

At her 2026-08-01 political debut in Lexington: “I've never had any desire to be a politician. I'm here today because I'm answering President Trump's call to serve. I want to stand up for South Carolina, and I want to fight for President Trump's agenda.”

“Men don't belong in women's sports.” (first campaign ad, released 2026-07-30)

Introduced the Lindsey O. Graham Sanctioning Russia Act of 2026 on 2026-07-16, modeled on her late brother's bill; it advanced on a bipartisan 86-12 procedural vote on 2026-07-28. “There is no greater way to honor Senator Graham's legacy than to move forward with this bipartisan agreement.”