Mariama James supports full Medicaid and Medicare funding, and opposes the '24 Option' that would reduce access to nursing home and rehabilitation services. She notes that healthcare is deeply personal in her district, especially for those affected by 9/11.

Mariama James supports building 100% affordable housing on the jail site, opposes NYCHA privatization and demolition, and aims to protect Elizabeth St. Garden. She emphasizes that housing in Lower Manhattan is disappearing and that longtime residents are being pushed out.

Mariama James defines public safety as creating communities where people feel secure, supported, and treated fairly, emphasizing accountability, prevention, mental health support, and investments that strengthen neighborhoods rather than policies that criminalize poverty or rely on mass incarceration.

Mariama James treats climate resilience, environmental justice, and quality of life as urgent priorities, citing the district's experience with Superstorm Sandy and rising sea levels.

Mariama James supports repairing or dismantling congestion pricing in Chinatown and the Lower East Side.

Mariama James supports anti-racism efforts.