Ortiz supports Medicare for All to ensure universal access to affordable, quality healthcare including gender-affirming care, abortion, fertility treatments, vaccinations, and full-service dental care. She believes healthcare should not be tied to employment and that politicians should not interfere in personal healthcare decisions.

Ortiz argues that ICE has repeatedly violated the Constitution and due process, with over 30 deaths in custody in 2025. She believes ICE cannot be rehabilitated and must be dismantled and abolished, and that Homeland Security Secretary Kristi Noem should be held accountable.

Ortiz pledges to introduce legislation that fully protects the rights of LGBTQIA+ people, homeless people, incarcerated people, and non-citizens. She wants to codify case law such as Bostock v. Clayton County and disparate treatment analysis to shore up civil rights protections.

Karen Ortiz believes it is Congress's duty to impeach, convict, and remove Donald Trump for unconstitutional actions and violations of his oath. She vows to introduce Articles of Impeachment on Day One if elected.

Ortiz calls for an arms embargo on Israel and an end to U.S. tax dollars funding what she describes as genocide of Palestinians and attacks on civilians. She advocates drastically reducing the military budget and redirecting funds to domestic needs.